Easy Tips to Get Fast Relief From Sinus Headache at Home: Sinus problems can lead to headaches, it is mainly due to pressure building up in your sinuses when the mucous membranes are inflamed and do not properly exude mucus. During a sinus headache, you can feel pressure and tenderness behind your forehead and around the eyes. The pain can be mild-to-severe as well as on one side or on both sides.